Analysis of data from the 2019 HABSelect trial now finds that selection of sperm cells for ICSI based on their binding to hyaluronic acid was indeed associated with a real reduction in miscarriage rate, especially in women over 35. HA-based selection of sperm for ICSI could now be considered a part of the treatment plan for older female patients, say authors.

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European Society of Human Reproduction and Embryology 2018-2020